Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p320 | (1) | WCRB2014

Pinacidil, a KATP channel opening drug, protects human oocytes against metabolic stress

Fernandes Goncalo M T , Gall Mandy , Drew Ellen , Barratt Evelyn , Madamidola Oladipo , Brown Sean G , Milne Alison M , da Silva Sarah Martins , Barratt Christopher , Jovanovic Aleksandar

Introduction: The primary treatment of infertility is assisted reproductive technology (ART). However, removal of an oocyte from its natural environment and exposure to in vitro conditions diminishes oocyte quality during the process of ART. In our preliminary studies we have shown that oocytes express cytoprotective ATP-sensitive K+ (KATP) channels. Therefore, the aim of our study was to elucidate whether activation of these channels protects hu...